Mrsa | MRSA Strain Spread Linked To Cfr Gene's Low Fitness Cost


A gene in methicillin resistant Staphylococcus aureus (MRSA)bacteria that confers multidrug resistance faces only alow barrier to spreading , according to a new study published in a scientific journal Tuesday.

The gene, called cfr, carries a slight “fitness cost” in theabsence of the antibiotics it protects against, according to thepaper, in Antimicrobial Agents andChemotherapy . Researchers performing the study includedscientists at TriusTherapeutics , a San Diego company now conducting clinicaltrials of a drug effective against MRSA, including strainsincluding the cfr gene.


Normally, a fitness cost substantially reduces the growth ofbacteria, a disadvantage outweighed by the benefits of antibioticresistance when the bacteria are exposed to them. The populations evolve resistance through mutations and by swapping genes. Butthe slight fitness cost of cfr suggests that it can spread intostaph bacteria even without the selection pressure of antibiotics,making development of new antibiotics more pressing, the paper’sauthors said.

Many drugs


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Methicillin-resistant Staphylococcus Aureus (mrsa): Etiology, At-risk Populations And Treatment (bacteriology Research Developments) Methicillin-resistant Staphylococcus Aureus (mrsa): Etiology, At-risk Populations And Treatment (bacteriology Research Developments)

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