As expected, nose tackle Isaac Sopoaga will not play today due to a reported staph infection and will be replaced by Ricky Jean Francois, who will be making his first career start.
Cornerback Shawntae Spencer (toe), however, is active after missing two practices this week. Spencer did practice Friday.
* The other 49ers inactives: QB Scott Tolzien, WR Braylon Edwards, CB Tramaine Brock, FB Moran Norris, G Mike Person, G Daniel Kilgore.
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* Tampa Bay inactives: WR Sammie Stroughter, S Devin Holland, LB Zac Diles, LB Quincy Black, G Derek Hardman,
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